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However, a possible conformational change in SufS upon SufE binding that may enhance substrate cysteine binding has not been excluded.
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However, these modelling results suggest some minor structural changes in the active site that may enhance subsequent substrate binding.
A pre-incubation step was used to enhance substrate specificity.
We speculate that the PEG moiety of A53C-his-PEG may disrupt enhanced substrate-substrate interactions in the enzyme's local environment, and thereby free individual alginate chains for more efficient enzymatic degradation.
An aberrant targeting of meprinβ in such conditions may have important functional consequences as it may enhance access to basolateral substrates, including E-cadherin.
The orientation of the particles as substrates may enhance the subsequent nucleation at the interface.
Our data also suggest that the formation of SUMO chains on substrates may enhance this targeting of Ulp1.
Most often, the formation of PS can create defects in the surface of the Si substrate that may enhance the gettering effect as extrinsic gettering effect.
These results suggested that WHI-P154 may enhance the cytotoxicity of ABCG2 substrates in cells expressing either wild-type or mutant ABCG2 (Arg482Gly/Thr or Phe489Leu).
It is thus possible that inhibitors of the activity of specific DUBs may enhance the degradation of specific substrates such as RTKs and thereby reduce cell tumorigenicity and bone tumor development.
We hypothesize that, as in mammals [ 58], the increase in capillarity as a result of exercise training may enhance the exchange of respiratory gasses, substrates and metabolites between the blood and fast muscle.
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