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Importantly, dopexamine, the agent most often used in trials of perioperative cardiac output-guided therapies, has a combination of vasodilator and mild inotropic actions, which may enhance microvascular flow and improve outcomes [ 12].
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That may enhance reputation.
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Recently it was shown that induction of heme oxygenase-1 may reduce ischemia/reperfusion injury, probably by enhancing microvascular blood flow [ 15].
In several diseases, the induction of TNF expression in resistance artery smooth muscle cells enhances microvascular myogenic vasoconstriction and perturbs blood flow.
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