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Recent reports suggest that alemtuzumab may enhance lymphocyte apoptosis in vitro in the absence of complement or immune effector cells, leading to cell death through a nonclassical caspase-independent pathway [43].
As recent reports suggest that alemtuzumab may enhance lymphocyte apoptosis in vitro in the absence of complement or immune effector cells [36], we ascertained its effects on NK cells.
Having observed elimination of T- and B-lymphocytes in the islets of cSN50-treated NOD mice (Fig. 2B and 2C), we hypothesized that intracellularly delivered cSN50 may enhance lymphocyte sensitivity to AICD, thereby reversing the known resistance of NOD lymphocytes to this process [30], [32], [33].
This correlative study, designed as a pilot study to investigate possible contaminant effects, led to a hypothesis that OCs may enhance lymphocyte proliferation.
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Vitro experiments indicated the secreted mCRT-sPD1 protein could bind to PDL1 and enhance lymphocyte proliferation and CTL activity.
Some studies show that they enhance lymphocyte responses to nonspecific mitogens and specific antigens and increase antigen-presenting capacity [ 41- 44], while others suggest that the role of fresh colostral leukocytes may not be as important as once thought [ 45].
The tested extracts significantly enhance lymphocyte proliferation at 1 mg/ml.
Mature DCs provide an interface between the innate and adaptive immune systems, acting as antigen-presenting cells [ 23], and may enhance cytotoxic T lymphocyte activation and function.
Glutamine may enhance the strong heat shock induction of monocyte and lymphocyte HSP72 proteins.
The immunoenhancement noted in these previous laboratory and environmental studies support the conclusions that OCs may enhance certain responses of loggerhead turtle immune cells and that lymphocyte proliferation may indeed be a useful biomarker of exposure to OCs.
However, we cannot exclude the possibility of polyclonal expansion of lymphocytes promoted by the malaria infection, which may enhance MOG35-55 specific T regs and thereby cause the phenomena described herein, albeit in smaller numbers.
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