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The biosynthetic gene clusters of the pks island may encode additional compounds that could mediate the probiotic activity observed in the gut.
Indeed, the total number of nucleotide sequences encoding A-domains belonging to this gene cluster may be even higher because of repeated DNA regions that are not included in the draft genome sequence and that may encode additional A-domains.
However, we cannot formally rule out the possibility that VARV or MPXV may encode additional secreted antitype I IFN activity distinct from the IFNα/βBP characterized in this report.
Consequently, our results indicate that some of these predicted proteins may have incorrect translation start positions, while other genes may encode additional products with the more conserved translation start [ 22].
The total number of nucleotide sequences encoding A-domains in strain XaS3 may be higher than 33 because of repeated DNA regions that are not included in the draft genome sequence and that may encode additional modules.
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These and other studies suggest that besides the information determining the amino acid sequence, DENV coding regions may also encode additional important signals associated with the folding strength of structural elements, which can be involved in different steps of the viral life cycle.
Of the 5,839 MER53 elements annotated in the hg18 genome assembly, we identified 44 Melementsmenthathat may encode miRNAs (Additional File 2).
Thus, in addition to canonical miRNAs and miRNA*s, miRNA precursors can encode additional sRNAs that may be functional under specific conditions like pathogen infection.
In contrast, such secondary phase shifts may be introduced by experimental design in order to encode additional NMR parameters, a new class of NMR experiments proposed here.
We determined that 29 candidate sRNAs had both an ORF and a corresponding RBS, suggesting that these sRNAs may encode small peptides (Additional File 5A, Type 1 & Additional File 5B).
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