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Identification of absolute insulin deficiency in patients with a clinical diagnosis of Type 2 diabetes may enable optimization of their treatment such as basal‐bolus regimens, management and education such as DAFNE courses 12, and recognition of potential complications such as higher risks of hypoglycaemia or ketoacidosis.
The prior characterization of mutations in FLT3, NPM1, RUNX1 and CEBPA together with the recent identification of mutations in IDH1, IDH2, DNMT3A and TET2 encourage the incorporation of genomic studies as part of routine clinical tests and may enable optimization of therapeutic plans based on this patient-specific genomic background.
Future studies are needed, to explore whether personalization of format and the level of detail of content (particularly relating to numerical data) of P-DAs to users' preferences may enable optimization of knowledge translation outcomes, or at least be non-inferior to current methods, but potentially preferred by some users.
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The findings in this work may enable the optimization of the design of under-rib convection-driven flow-fields for efficient PEMFCs.
Combining the best features of both the methods may enable multiscale optimization studies involving both the bioreactor scale (macroscale) and the pore scale (microscale).
Furthermore, such studies may enable the optimization of parylene protein interactions toward the neuralization of progenitor cells, which is an area receiving strong interest.
This being said, it could also not be denied that diagnostic imaging and tumor markers have not yet proved to be accurate enough in the evaluation of tumor extent to replace surgical staging although it may enable an optimization of the surgical procedure and result in a better tailored therapeutic strategy.
To enhance the dynamic range, it may be necessary to use circularly permuted Venus variants to enable optimization of relative orientation between RLuc8 and Venus.
The realization of mechanisms will enable optimization of chemotherapy for the treatment of cancer [18].
A "plug and play" methodology comprising a generic linking apparatus may enable rapid design and optimization.
These recent studies show the potential of RMS for non-invasive monitoring of stem cell differentiation, which may enable a more efficient optimization of the relevant bioprocesses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com