Through manipulation of their elemental composition, size, shape, charge and surface modification or functionalisation it may be possible to target particles to specific organs where they may elicit their therapeutic effect.
Evidence supports the clinical relevance of centrally sensitized pathways in migraine and drugs clinically effective in migraine, such as NSAIDs, may elicit their actions primarily through central sites.
BPs may elicit their proposed anti-angiogenic effects through inhibiting maturation and/or proliferation of endothelial cells (ECs), by affecting their adhesion, or by reducing their ability to migrate and form functional vessels.
Our results are the first to identify a potential DNA repair enzyme target for lead and suggest a means by which these prevalent environmental metals may elicit their deleterious effects.
According to the ceRNA hypothesis, lncRNAs may elicit their biological activity through their ability to act as endogenous decoys for miRNAs; such activity would in turn affect the distribution of miRNAs on their targets (Salmena et al., 2011).
The fact that only spontaneously active cells (generating episodic Ca waves without any stimulation) typically responded to these estrogens indicates indirectly that E2 and these xenoestrogens may elicit their actions by changing resting potentials.
