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However, broad neutralisation may elicit intolerable toxicity; besides the thrombocytopenia caused by BCL-xL inhibition, loss of MCL-1 function shows a variety of toxic effects in mice though it is important to note that effects of transient pharmacological inhibition does not equate to irreversible loss of MCL-1 function induced in these mice (Thomas et al, 2013; Wang et al, 2013).
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