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The expression of a foreign protein at a high level may either directly limit other cellular processes by competing for their substrates, or indirectly interfere with metabolism, if their manufacture is blocked, thus inducing a stress reaction of the cell.
All of these may either directly strain your cardiovascular system or promote some of the aforementioned conditions (e.g., high blood pressure, diabetes, or heart conditions) that then put you at higher risk for stroke.
Our data suggests that IRAK-M may either directly or indirectly induce HDAC-2 production.
In the hippocampus, P2X7R stimulation may either directly or indirectly activate neurons and elicit changes in their excitability [36], [37], [40].
If mtDNA mutations affecting longevity exist, they may either directly confer a selective advantage, or, they may compensate for deleterious mutations on other loci (associated with mtDNA or nuclear genes) or be detrimental (confer a selective disadvantage).
Thus, the increase in DNA binding is likely attributed to AICAR-mediated post-translational modifications (i.e. phosphorylation) that may either directly or indirectly affect the transcriptional activity of GATA-4 or USF-1.
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The structural equation modeling is a method for representing, estimating and testing a theoretical network of mostly linear relations between variables that may be either directly observable or unobservable and may only be measured imperfectly.
We speculate that mutations at the newly discovered sites may be either directly responsible for drug-resistance or may play compensatory role by accompanying other drug-resistance mutations and diminishing their negative effects, e.g. the decreased replication rate.
Furthermore, choice of Gb dosage strength may be related to physician factors such as prescribing preference, which in turn may be either directly or indirectly associated with different persistence with drug therapy.
This process may either occur directly where epithelium can trans-differentiate into pre-adipocytes; or indirectly where first epithelial to mesenchymal transition (EMT) occurs followed by subsequent pre-adipocyte differentiation.
The observed variation in overnight cortisol level may either be directly involved in the physiologic pathways leading to the prolongation of the IOI period or be a consequence of said prolongation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com