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PLK2 inhibition may effectively sensitize osteosarcomas to cisplatin treatment through the enrichment of TAp73.
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In the present investigation, low concentrations of ouabain and the induced hybrid cell death mechanism effectively sensitize drug-resistant glioblastoma cells to the anti-cancer effect of TMZ.
We have recently shown that trastuzumab can effectively sensitize ErbB2-overexpressing breast cancer cells to paclitaxel by reversing the antiapoptotic function of ErbBZ.
Therefore, Rap can effectively sensitize Raji cells to Dex-induced apoptosis.
We have demonstrated that rapamycin (Rap), a mammalian target of rapamycin (mTOR) inhibitor, can effectively sensitize anaplastic lymphoma kinase-positive lymphoid cells to dexamethasone (Dex -induced apoptosis [ 2].
We observed that TNFα or IFN-γ alone exhibits minimal sensitization effects, but effectively sensitized metastatic colon carcinoma cells to TRAIL-induced apoptosis when used in combination.
UV vis transmission spectroscopy and photoelectrochemical solar cell measurements demonstrate that CdSe effectively sensitizes ZnO nanowires to visible light.
Our results indicate that T-cells can be effectively sensitized by in vitro methods and used as cellular probes to identify and differentiate glioma from radiation necrosis.
Each rabbit was effectively sensitized with heat-killed M. bovis and all converted their tuberculin skin tests to positive prior to infection similarly to previous work (Table 1) (18).
To extend the above findings that specific shRNAs against RELA and STAT5B effectively sensitized chemoresistant ovarian cancer cells to carboplatin killing, we sought to determine the effect of their small molecule inhibitors as potential chemosensitizers.
We demonstrated here that combined treatment of TNFα and IFN-γ, two physiologic cytokines of the host immune system, effectively sensitized metastatic human colon carcinoma cells to TRAIL-induced apoptosis (Fig. 1).
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