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It is therefore plausible that alterations in AR phosphorylation may drive prostate carcinogenesis.
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The data presented here suggest that a microenvironment of PPAR γ2-mediated fatty acid metabolism by stroma or adipose may drive prostatic epithelial differentiation; however, under conditions of diabetes and obesity fatty acid supply may become saturated, leading to inflammation and hyperplasia in prostate disease.
Weakening of integrin-mediated cell adhesion to the extracellular matrix may initiate and drive prostate tumorigenesis.
Phosphorylation of this site via a high affinity interaction with ERK2 was necessary for ERG function in prostate cells and indicates that low level RAS/ERK signaling may be required for ERG to drive prostate cancer.
Forbes reported earlier this year on a study from Wake Forest Baptist Medical Center researchers, showing that stress seems to make prostate cancer drugs work less effectively, and drive prostate cancer development.
In prostate tumor cells, COUP-TFII counteracts the TGF-β-dependent growth barrier to drive prostate tumor growth and metastasis [ 16].
As for prostates, a rat probasin promoter has been widely used to drive prostate-specific gene expression.
We performed a sensitivity analysis, cumulating all randomized clinical trials (RCTs) in which patients with metastatic castration-resistant prostate cancer (mCRPC) received systemic therapy, to evaluate if the comparison of RCTs may drive to biased survival estimations.
This may drive compulsive overeating.
Managers may drive 150km in a shift.
Either sort may drive the wheels.
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