Taken together, the phenotypic and expression analysis of dCTCF alleles indicates that both CTCF EY15833 and CTCF 30 alleles have reduced dCTCF expression and that the 5' end of P{EPgy2} may drive sufficient expression to allow recovery of CTCF EY15833 adults.
Since each CNE may drive reporter expression to one or more anatomical annotations, we have also quantified the percentage of the affected expression domains per CNE.
When inserting transcriptional terminator sequences care must be taken to control for changes in spacing between DNA regulatory elements and to take account of regulatory elements that may be inadvertently inserted, such as promoters of resistance genes, since these may be able to drive expression of neighbouring genes or divert activities from nearby enhancers.
Such shared regulatory mechanisms may drive gene expression in the same way in each time series, or they may be modified to drive expression on a different time scale or to change the direction of regulation (activation versus repression).
In particular, the number of ramified precursors expressing both Olig2 and GPR17 is very high, to suggest that Olig2, which is a transcriptional factor, may drive the expression of GPR17 in these cells.
Endogenous sources of DNA replication defects may drive the expression of FA symptoms.
As a transcription factor, ATF-2 may drive the expression of genes implicated in autophagy induction.
Therefore, in the present study, we investigated the hypothesis that hypoxia may drive the expression of leptin and DKK2 in OA Obs.
However, Eames et al. had proposed that a unique combination of Sox9 and Runx2 may drive the expression of the major marker of hypertrophic chondrocytes, Col10, based on the analysis of Sox9 and Runx2 functions in primary cartilage differentiation of the avian cranial skeleton [ 36].
For instance, a cardia specific promoter may be more appropriate to drive expression of an anti- Plasmodium factor that target gametocytes, zygotes and ookinetes in the midgut lumen as it potentially would allow the factor to blend into the ingested blood meal.
