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BFRs may disrupt proper endocrine function by multiple mechanisms including hormone signaling, transport, and metabolism.
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Those additional forces may disrupt the proper orientation.
It is conceivable that the familial D620N mutation may disrupt the proper retromer-dependent trafficking of cargo proteins.
For those subjects with no known etiology to explain TOF, we hypothesize that because of the similarity of the defect in the outflow tract, these children share a common developmental deficiency that may arise from different root causes, but underlying factors converge to disrupt proper temporal and spatial cell lineage specification leading to developmental deficiency.
Ensuring that each enzyme functions effectively can be challenging, since many potential factors can disrupt proper pathway flux.
Different factors, including changes in genome copy number, can disrupt proper gene functioning.
The G allele of rs4963 has deleterious effect by disrupting the activity of exonic splicing and thus disrupt proper gene regulation [ 23].
The S151A-human-SGCD may act as a dominant negative isoform.[6] Accordingly, the expression of the S151A-SGCD may disrupt or, at least, alter the proper functioning of dystrophin glycoprotein complex thereby inhibiting extracellular signals that are necessary to maintain normal myocyte function.
Attaching items to a heat sink's fins may disrupt the air flow they were designed to generate, and reduce its effectiveness, at least if proper mating is not achieved.
Greater national attention may disrupt its sense of isolation.
But even if your device doesn't go off it may disrupt your sleep.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com