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Greater national attention may disrupt its sense of isolation.
Interestingly, R229 is located in a highly basic region of the F3 sub-domain and the removal of one of the basic charges may disrupt its binding site for interacting partners or with the phospholipid membrane.
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miRNAs drive tissue regeneration, and their dysregulation may disrupt it.
A deletion within the trnV -CAU intron also reported in C. reflexa [ 21], and similar to that seen in Orobanche minor, may hypothetically disrupt its splicing [ 13], but because both exons remain intact in these species, we hesitate to call it a pseudogene in C. exaltata without experimental evidence.
It also reflected concerns by the Chinese government that Tibet activists may try to disrupt its plans to carry the Olympic torch up the world's tallest peak.
DNA rearrangements involving a TE after its insertion into the genome may disrupt colinearity of its sequence with a reference element.
Such an assay would be expected to reflect the contribution of multiple overlapping and independent activities and also to establish whether loss of a single activity may be sufficient to disrupt its overall function as a tumour suppressor.
This backup mechanism prevents accumulation of excessive apo-IRP1 in iron-loaded cells that may disrupt iron homoeostasis by its unregulated IRE-binding activity.
Interestingly, an IS 256 inserted upstream of traR in the CIAT 899 pSym may have disrupted its promoter leading to a constitutive repression of the conjugation system of this plasmid.
But its dominance may disrupt the balance of some ecosystems through cascading effects as a consequence of changes in interactions between species.
Mutations in IL-10 or its receptors may disrupt their interactions, thereby preventing IL-10 signaling.
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