Exact(4)
For example, alteration in TNFRSF10B transcript abundance may disrupt cell cycle control and induce the development of carcinogenesis.
Disturbances in cholesterol homeostasis may disrupt cell membranes where α-syn appears to exert some of its functions [ 101, 105].
Since the phenotype involves cell rounding and detachment, inhibition of MP1expression may disrupt cell adhesion signals, which could then trigger cell death.
Fatty acid-free BSA is used because the fatty acids in normal BSA can bind to the phospholipids in the cell membrane and this may disrupt cell morphology and behavior.
Similar(56)
During the developmental phase, the enlargement may disrupt cell-to-cell signaling that is necessary for the development of hearing.
Expression of E7 protein in these cells may disrupt cell-cycle checkpoints, leading to tetrasomy, and our data suggest that this property requires phosphorylation of the S31/S32 site.
In this scenario, untamed autophagy induced by DNA-damaging agents may disrupt cells' homeostasis, contributing to cell death.
The enlargement of the cochlea lumen may not only disrupt communication between mesenchymal and epithelial cells but may also disrupt cell signaling between adjacent epithelial cells.
Caspases (cysteine-dependent proteases) and transglutaminase are some of the thiol-dependent enzymes involved in apoptosis, so inhibition of these thiol-dependent enzymes in tumor-initiated cells may disrupt apoptotic cell death and aid in tumor survival.
The micelles' presence in the cell or alteration of the cell's surface charge, she says, may disrupt the cell's normal functioning.
By causing an increase in acetylated histones and other proteins, HDAC inhibitors may disrupt the cell cycle and induce apoptosis of tumour cells by targeting cell cycle checkpoint controls – a G2 check point, which is often defective in tumour cells, and a mitotic spindle check point (Warrener et al, 2003).
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