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This arhitecture and the high degree of conservation of the FH2 domain allow some preliminary conclusions about the functionality of Dictyostelium formins: all isoforms may display actin nucleation activity and, with the exception of ForI, may also be susceptible to autoinhibition and to regulation by Rho GTPases.
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Surprisingly, even at permissive temperature, these cells did not display actin bodies, but rather depolarized actin patches and an abnormally dense network of non-polarized actin cables (Figure 2C and data not shown).
We have taken advantage of the fact that yeast quiescent cells display actin bodies, a non polarized actin structure, to evaluate the role of F-actin in bud emergence.
Thus, potential agents targeting the osteoclast formation of actin rings or sealing zones may display favorable effects in combating resorptive bone diseases.
As discussed in preceding sections, cells adhering on laminins may display less activation of the small GTPase RhoA, fewer actin stress fibres, smaller focal adhesions, and enhanced stability of cell cell junctions, compared with cells adhering on other integrin ligands.
It is important to note that VASP may display other biochemical activities, which may not be affected by phosphorylation (e.g. actin filament bundling) in adhesions located at the ends of ventral adhesions.
Loggerheads may display multiple paternity.
Church of England clergy may display chivalric insignia.
Certain subpopulations may display specialization.
Larger lesions may display dense focal calcifications.
This may display the location.
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