Sentence examples for may directly upregulate from inspiring English sources
The bacteria may directly upregulate MDM2 expression or the upregulation could be a response of the eukaryotic cell to the pro-survival state seen.
Thus, SOX2 may directly upregulate cyclin B1 expression in HNSCC.
Statins prevent downregulation of endothelial nitric oxide synthase and may directly upregulate its activity, leading to increased bioavailability of nitric oxide.
Using the transcription factor database search tool DECODE (SaBiosciences) and data from the University of California Santa Cruz Genome Browser, we identified potential two κB-binding sites in the IL-10 promoter (unpublished data), suggesting that p80HT may directly upregulate IL-10 expression.
In addition, Dll4 expression by endothelial cells may be directly upregulated by hypoxia, possibly via Hif1- α and hypoxia response elements in the Dll4 promoter (Patel et al, 2005; Diez et al, 2007).
Furthermore, OTX2 has been shown to directly upregulate the expression of c-MYC in medulloblastoma via cis-regulatory elements in the MYC promoter region [91, 92].
Subsequently stretch would directly upregulate ANKRD1 transcript and launch Ankrd1-mediated survival cascades.
Snail and SIP1 may not directly upregulate MMP transcription and further analysis is necessary to clarify how Snail or SIP1 activate the transcription of MMP family.
Although some investigator observed that oocyte-derived factors such as GDF-9 directly upregulated Cyp17 mRNA and protein expression in rats [ 9, 10] and paracrine regulations of GCs may also enhance steroid production in whole follicles, many aspects of the signaling network among different groups of follicular cells, especially their effects on steroid synthesis, remain to be investigated.
In addition, FOXC2 directly upregulates the expression of ZEB1 by binding to its promoter region (Werden et al., 2016).
The present study provides a direct evidence, for the first time that TRH directly upregulates TSH β gene expression in teleosts.
