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Therefore, we conclude that the presence of TP mRNA in a subset of cultured nodose ganglion neurons allows for the possibility that TXA2 may directly stimulate or modulate vagal afferent neurons.
Our in vitro data suggests that IL-6 and TNF-α may directly stimulate sEpoR production.
Immunoprecipitation studies have demonstrated an association of the p85 regulatory subunit of PI3K with type II BMP receptors as well as with TGFβ receptors [24], [37] suggesting that type II BMP receptors may directly stimulate PI3K activity and thus play a role in the generation of acute BMP responses.
Instead, relaxin may directly stimulate cell differentiation in vivo.
There is an ongoing debate whether EPO may directly stimulate platelet production.
Alternatively, a decrease in cell viability may directly stimulate cellular proliferation as occurs in tissue repair.
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Dr Tyler now believes that tDCS may not directly stimulate the brain at all but instead modulates cranial nerves in the skull, like the headache-busting TENS technology.
Cognitive activities may also directly stimulate neuronal systems, enhancing neural pathways responsible for cognitive functions, such as memory and language.
Furthermore, neutrophil-recruiting cytokines such as GRO (IL-8 homologues) may also directly stimulate tumour proliferation in melanoma (Haghnegahdar et al, 2000).
Breast cancer cells may also directly stimulate osteoclast-mediated bone resorption by interacting with preosteoclasts through the Jagged1-Notch pathway [ 4].
Increases in IL-1 may both directly stimulate the expression of MMP-10 and cause indirect increases in MMP-10 expression through stimulation of NGF expression.
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