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Consequently, in these studies, the SiO2-NP reach viable epidermal layers and may directly interact with keratinocytes and immune cells.
Later study indicated that the representive compound 8u may directly interact with survivin protein and induce HepG2 cells apoptosis, which is different from YM155.
Alkylation of carbazol-4-one DKA nitrogen (6a c) led to a loss of activity, suggesting this nitrogen atom may directly interact with the active site of integrase.
Aβ oligomers may directly interact with the synaptic membrane, leading to impairment of synaptic functions and subsequent signalling pathways triggering neurodegeneration.
Galectin-4 may directly interact with the CD4+ T cells through binding to the immunological synapse, which is a specific activator of the protein kinase C (PKC) θ-associated signaling cascade in lipid raft (Hokama et al., 2004; Nagahama et al., 2008).
The promise of nanotechnology lies in the possibility of engineering matter on the nanoscale and creating technological interfaces that, because of their small scales, may directly interact with biological objects, creating new strategies for the treatment of pathologies that are otherwise beyond the reach of conventional medicine.
We hypothesized that this region of gp120 may directly interact with chemokine receptors.
Several studies suggested that KCNE1 is close to the conduction pathway and may directly interact with the S6 segment of Kv7.1 [15] [17].
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In addition, Puma may also directly interact with and activate Bax/Bak, for example, through an interaction with the first α-helix of Bax.
These data showed that SIP1 could play a critical function as an IN-cofactor, but may not directly interact with the RT.
Collectively, these results suggest that ATR may not directly interact with NR5A receptors, but instead activates three signaling pathways known to activate NR5A receptors, including phosphorylation of SF-1, generation of SF-1 ligands, and increased production of cAMP.
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may directly S-sulfhydrate
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