Sentence examples for may directly effect from inspiring English sources

Finally, lead may directly effect or substitute for calcium in the active sites of the calcium messenger system, resulting in loss of physiological regulation.

The lack of alteration in sperm parameters and sex hormone levels suggested that BPA may directly exert its effect on the testes.

Metformin reverses endogenous hyperinsulinaemia through its effects on glucose homeostasis and therefore may directly have antiproliferative effects [ 36].

On the other hand, the bacterial immunogens entering the mammary tissue may directly exert harmful effects on the mammary epithelial cells, which may lead to depressed functions and proliferation of the epithelial cells and increased cell apoptosis.

As 50% of CDHP is excreted in the urine, renal dysfunction may directly affect the inhibitory effect on dihydropyrimidine dehydrogenase and lead to increased 5-FU concentrations.

Although we cannot exclude with certainty the role of t-Ag and other T'- proteins, based upon our results it is reasonable to speculate that T-Ag may be the primary mediator of a metastatic phenotype in colon cancer cells, and some of these effects may directly or indirectly be influenced by the activation of AKT/MAPK pathways [44], [45].

These effects may directly contribute to the improvement in glucose regulation and insulin sensitivity.

These effects may directly or indirectly involve the genetic material and result in developmental perturbations, abnormal embryogenesis and malformations.

Even mental health effects may directly or indirectly be attributed to climate change, e.g. as a consequence of wars and conflicts caused by climate change related developments.

Due to the strong dependency of neoplastic mast cell proliferation on the constitutively activated KIT it was hypothesized that the observed effects may directly or indirectly be caused by the inhibition of KIT [ 1, 13].

MPIO have been demonstrated to provide a platform for quantitative molecular imaging of vascular endothelial targets, whereby the extent of contrast effects may directly report specific molecular endothelial expression [9 11].