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TLR2 may diminish response to mycobacterial proteins and place individuals at risk of developing leprosy.
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Nevertheless, Giardia may have an impact on mucosal integrity and function that may diminish responses to oral vaccines.
However, information about differences in the amniotic fluid proteome at the end of labor, when activation of prolabor inflammatory pathways may diminish the response to infection, is lacking.
Similarly, cell extrinsic inhibitory factors present within patients' bodies may diminish proliferative responses.
The apparently attenuated response to α1-adrenergic agonists in vivo may reflect diminished response to these normally synergistic vasopressor pathways.
In the context of increasingly hectic lives, surveys that are perceived to take too long to complete may not be viewed favorably and may bring about diminished response.
As is true for any drug, biologic agents do not achieve optimal response in all patients, and response may diminish over time in some patients.
These findings suggest that ECs in SSc may have a diminished response to these chemokines based on the downregulation of their receptor.
WD would not only overstimulate sebum production favouring P. acnes growth but may diminish AMP-controlled host responses against P. acnes, which may ultimately stimulate inflammatory TLR-mediated innate immune responses against hypercolonized P. acnes 93, 94.
Receptor desensitization and ion channel fatigue are also factors that may contribute to the diminishing response with repeated mechanical loading (Ralevic and Burnstock 1998).
Low-carbohydrate diets may diminish triglyceride production in the liver in response to decreased carbohydrate delivery [ 14].
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