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Nevertheless, these observations pose therapeutic possibilities and indicate that various chemokines may differently regulate breast cancer development, depending to a large extent on the type of leukocytes they attract.
The signalling pathways modulating the pro-inflammatory and anti-inflammatory mechanisms seem to involve steroidal hormone receptor activation and the NF-κB complex factors, In addition, oestrogens may differently regulate NF-κB activation depending on the cell type tested [ 14, 31].
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It is reported that autophagy may be differently regulated in different compartments of the neuron.
LDHB stop suppression is thus not restricted to special tissues, and may be differently regulated in different cell types.
It remains to be investigated, but this also shows that autophagy may be differently regulated in different compartments of the RGC.
Taken together, these experiments show that BTR is indeed a property of the respective SCC, and that readthrough may be differently regulated in different tissues.
Different 5′UTR ends present in various tissues may serve to differently regulate gene expression in response to physiological and pathological stimuli through mechanisms involving not only transcription but also translation efficiency.
The observed differences in the extent to which US2 and US11 inhibit expression of HLA-ABC on the surface of hMSCs may relate to the fact that these immunoevasins depend on distinct cellular proteins for their activity, which may be differently regulated in hMSCs.
In contrast, it has been found in healthy humans that plasma concentrations of VEGF decrease upon hypoxia under in vivo conditions, indicating that systemic VEGF concentration may be differently regulated than cellular expression.
In fact, the persistently high 18F-FDG uptake after therapy is a reliable imaging biomarker of tumor resistance whereas the early reduction of tracer uptake during treatment does not univocally indicate tumor sensitivity to EGFR inhibitors since glucose metabolism and proliferation may be differently regulated depending on the cellular context.
Also, mitochondrial matrix levels of superoxide may be differently regulated from cytosolic ones.
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CEO of Professional Science Editing for Scientists @ prosciediting.com