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We proposed a model as depicted in Fig. 5C, during preimplantation development, key cell division kinases such as AurkB and C may differentially regulate mitosis timing and the activities of pluripotency transcription factors thus to influence cell position, gene expression and these effects cumulate to impact cell fate decisions.
Our results provide a mechanistic explanation on how ER stress may differentially regulate a variety of cellular responses via the AKT pathway in a severity-dependent manner.
The frequency of CD11bhi CD27– mature NK cells was somewhat higher in the B6 mice than any of the other strains, suggesting that a factor other than CD94-NKG2 expression may differentially regulate NK cell development in B6 vs. 129/SvJ mice.
We hypothesized that Lck hyperactivation may differentially regulate strong and weak agonists.
Alternatively, they may differentially regulate the same genes, with the outcome depending on, e.g., environmental conditions.
A recent report suggests that KiSS1 may differentially regulate matrix metalloproteinases (MMPs).
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Our results rather suggest that the two MEK isoforms may be differentially regulated or may target distinct effector pathways in certain cellular and/or genetic contexts.
There is much evidence to suggest that different fetal compartments may be differentially regulated and thus growth may not be concordant across these measurements.
Because mammary glands from virgin mice have less epithelial cells than progestin-treated mice, and on the other hand both stroma and epithelium may express steroid receptors, which may be differentially regulated, we only quantified the ratio between both isoforms in the same blot.
These suggest that remyelination in adult brain may involve multiple populations of progenitors within the brain and that OPC differentiation in adulthood may be differentially regulated compared to development.
Even more, comparisons between the miRNA profiles of WM tumors and those of CLL and MM may reveal differentially regulated miRNAs involved in abnormal differentiation of B lineage cells.
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may differentially impact
may differentially contribute
may differentially effect
may differentially improve
may differentially target
may differentially interact
may differentially respond
may differentially impede
may differentially benefit
may differentially associate
may differentially influence
may differentially control
may differentially utilize
may differentially alter
may differentially modulate
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