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Patients may develop significant renal, pulmonary, or neurologic disease from SS.
At least experimentally, almost all mammals are receptive to T. evansi, but only some of them are susceptible and may develop significant clinical signs and play a role in its epidemiology, as described below.
Patients undergoing CTS may develop significant pulmonary derangements and complications related to the reduction of lung expansion and compliance; clinically, in these patients dyspnoea and pain are the dominant symptoms, especially during minimal efforts.
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ID, defined by two or more abnormal measurements (serum ferritin, transferrin saturation, erythrocyte protoporphyrin), is insidious and uneasily detected by patients themselves and may not develop significant clinical symptoms [ 1- 4].
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These may develop without significant thrombocytopenia in 15% of patients [ 18].
Patients who develop significant respiratory depression may need treatment with naloxone; this is while naloxone has a short duration of effect in contrast to most opioids.
While the disease has manifested itself by the age of 25 years in most cases, some affected individuals may escape developing significant symptoms throughout their lives.
This may indicate that these oncogene-driven models do not develop significant genome instability and secondary genetic alterations.
87 Vincristine-induced peripheral neuropathy is dose dependent, as up to 60% of patients may develop a clinically significant (grade 1 2) primarily sensory or sensorimotor neuropathy at vincristine cumulative doses between 30 50 mg.
92 Suramin-induced peripheral neuropathy is dose dependent, as up to 60% of patients may develop a clinically significant (grade 1 2) primarily sensory or sensorimotor neuropathy at suramin plasma peak levels higher than 350 μg/mL.
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