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Clinical course and complications As mentioned above, patients may develop severe reflux esophagitis with stricture formation.
Clinical course and complications Patients with LES hypotension and GERD may develop severe reflux esophagitis with stricture formation as well as supraesophageal complications.
Distinguishing inactive hepatitis B surface antigen (HBsAg) carriers from hepatitis B e antigen-negative hepatitis remains difficult but is important because patients with active hepatitis may develop severe complications.
In addition, with progressive volume loading patients may develop severe tissue edema, which compromises tissue oxygenation.
Patients with homozygous or compound heterozygous −28 (A>G) mutation may develop severe anemia or intermedia anemia (Cao and Galanello, 2010; Orkin et al., 1983).
ELBW infants are particularly fragile individuals who may develop severe diseases.
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The radiographs are initially normal but patients may subsequently develop severe osteopenia.
Vitiliginous SL chickens may also develop severe visual impairment and blindness due to autoimmune activity directed against choroidal melanocytes and subsequent damage to the retinal pigment epithelium.
In South America, the lesser known though more virulent Bartonella bacilliformis causes Oroya fever and verruga peruana in humans, and infected patients may develop a severe, life-threatening hemolytic anemia [ 8].
Although a large proportion of patients recover after a mild self-limiting disease, a small proportion may progress to develop severe dengue clinical manifestations, which require interventions in intensive care unit (ICU).
Consideration of the clinical features and severity of smallpox is important from the standpoint of mathematical transmission modeling because (1) the clinical features affect the ease of diagnosis (and thus of case identification), (2) more severe forms of smallpox may result in more transmission, (3) vaccinated individuals may develop less severe disease.
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