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These ApiAP2 proteins, in addition to regulating heterochromatin formation and genome integrity, may develop novel parasite-specific functions such as antigenic variation, invasion, and sporozoite development [ 92- 95].
Second, pathogens may develop novel traits while circulating in a given host.
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Identifying mechanisms involved in lung CSC regulation may help develop novel, effective cancer therapies.
Understanding the mechanism underpinning the iron overload associated with insulin resistance may help develop novel therapies for Type 2 diabetes.
Understanding the mechanisms that control endothelium transdifferentiation to osteochondroprogenitors and the subsequent vascular calcification may help develop novel strategies that prevent or reverse vascular calcification.
Learning the pharmacology of SLURP-1 and -2 actions on enterocytes, colonocytes, T cells, and macrophages may help develop novel effective treatments of IBD.
Uncovering the transcriptional and post-transcriptional regulatory networks governing the Schwann cell injury response is a key step towards a better understanding of Schwann cell biology and may help develop novel therapies for related diseases.
These findings may lead to develop novel metal based drugs.
These findings may help to develop novel therapeutic targets to prevent critical illness-induced bone loss.
A better understanding of TF-DNA interactions within SNCA may allow to develop novel therapies designed to reduce α-synuclein levels.
Understanding the substrate specificity and the kinetics of fatty acid conjugation may help to develop novel analgesics that are more effective and less toxic than acetaminophen.
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