Since genomic instability occurs not only among cases but also among controls, some of these high-risk controls may eventually develop lung cancer later and our cross sectional study design does not address this risk.
Even in the presence of high cruciferous vegetable intake, smokers may still develop lung cancer, especially if they continuously smoke for a long enough time.
Diabetic patients may develop acute lung injury less often than non-diabetics; a fact that could be partially ascribed to the usage of antidiabetic drugs, including metformin.
Pulmonary involvement is uncommon in vasculitis associated with Sjögren's syndrome, although patients may develop interstitial lung disease, pulmonary hypertension, or lymphocytic interstitial pneumonia.
This is also relevant as the proportion of COPD patients who eventually develop lung cancer may be as high as 25 30% [8], [77] and the frequencies of several disease-related SNPs are very similar between lung cancer and COPD groups (See Table 3, eg FAM13A, HHIP).
The strength of this study is that within young cases the genetic component to develop lung cancer may be greater.
Diabetics who develop lung cancer while receiving metformin may have a more aggressive cancer phenotype.
Even with the high attributable risks due to cigarette smoke exposure, only 10 15% of all smokers develop lung cancer [3], suggesting genetic variability may play a role in susceptibility to lung cancer.
Some smokers may be more susceptible to DNA damage from tobacco smoke and thus more likely to develop lung cancer.
He explains that although cancer may only occur in 20percentt of smokers, we shouldn't ignore the fact that smokers are 20 times more likely to develop lung cancer.
