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Thus, detection of hypo-autofluorescence on FAF may help the clinician in predicting the areas of the retina that may develop loss of function in the future.
Serious cases may develop loss of consciousness or coma, and may need intubation and artificial ventilation.
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Others may experience unsteadiness or lack of coordination due to involvement of the cerebellum, and still others may develop visual loss (on one side of the visual field) due to involvement of the visual cortex in the occipital lobe.
Given the importance of mutant SOD1 protein dose in accelerating the ALS-like phenotype (16), it is possible heterozygotes may develop UMN loss later in life.
These results imply that over 70% of patients with JUPHL may develop contralateral hearing loss and that we have to follow-up patients with unilateral juvenile profound hearing loss for a long time.
Patients may develop insomnia, weight loss, chronic fatigue, and an inability to perform daily activities.
Thus, if TGF-β1 is abundantly expressed within OA joints, osteophytes may develop without the loss of cartilage matrix.
Due to pain during eating, weight loss may develop as a result of not eating in severe cases of aphthous stomatitis.
Severe visual loss may develop, including blindness.
Retinal vein occlusion (RVO) is a common retinal vascular disorder in which different complications, including macular edema, may develop with a consequent loss of central vision [ 1].
Although it has been described as an entity separate from CHED, a recent study suggests that some degree of hearing loss may develop in all individuals with time [ 33, 34].
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