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Many patients with CRC may develop liver metastases at some point during the course of their disease [ 3].
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Infected people often show no symptoms but may eventually develop liver cancer, cirrhosis or other liver diseases.
Only 20 30% of HCV infected people will recover spontaneously, while the majority of infected populations with persistent infection may subsequently develop liver fibrosis, liver cirrhosis (LC), and hepatocellular carcinomas (HCC) [ 2].
The understanding of the natural history of HCC is hampered by the variability of the tumour, which is influenced by the co-occurrence of multiple co-morbidity factors in the same patient as well as by the presence of multiple distinct cell lines in the liver that may develop into liver cell cancer [ 4].
Although the majority of patients do not develop complications, 28% may develop serious liver sequelae, including end-stage liver disease and hepatocellular carcinoma [ 1- 5].
Without early diagnosis and treatment (fetal delivery), the patient may develop acute liver failure and hepatic encephalopathy.
In addition to hematologic morbidity such as bleeding and thrombosis, patients may develop chronic liver injury that progresses to cirrhosis.
Although breast cancer frequently metastasizes to the bones and brain, rarely breast cancer patients may develop isolated liver metastasis.
If a glass of wine per day may protect the heart, the excess may increase the risk to develop liver or cardiovascular diseases.
Liver transplantation may also be curative, but this drastic measure is reserved for the small percentage of patients who do not respond to the usual treatment or who develop liver cancer.
For example, only 30percentt of alcoholics develop liver disease.
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