Trastuzumab resistance may also develop, limiting trastuzumab's ability to maintain disease control in the advanced as well as early stage disease settings [ 12].
Many patients will have been treated with other regimens and resistance to some of these therapies may have developed, limiting the choice of other therapeutic options.
Some point to the phenomenon of deformed preferences: when attractive options are limited or arrangements unfair, people may develop preferences for those limits or for less than their fair share (Nussbaum 1999a, 33, 50; Cudd 2006, 152).
Corneal scarring was also one of the ocular morbidity seen in the study groups, and leads to visual impairment that is difficult to treat except with corneal surgery, which may not be easily available to the population; then, in addition, it is even more problematic in childhood because amblyopia may develop, which can then limit the benefits of surgery later in life.
Critically ill patients may develop immune paralysis (anergy) that limits their ability to mount immune responses; therefore, it is important to note that negative serology does not exclude CMV infection.
Consequently, it has been proved that instabilities and failure may develop before reaching the classic failure limit given by a plasticity limit.
With three steady states, a state may develop into a stable or unstable limit cycle or may exhibit only periodic solutions without a limit cycle.
Due to time-limited mechanical support of the trachea, re-stenosis may develop during degradation of the stent.
However, when repeated loading deviates from normal limits by differences in magnitude, frequency, duration, and direction, overuse injury may develop.
"Alternate identities may develop instead".
