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But about a half-hour later, a constellation of symptoms may develop, including muscle cramps, vomiting and hypertension.
Severe visual loss may develop, including blindness.
In 5% to 9% of CSD patients, atypical manifestations may develop, including Parinaud oculoglandular syndrome, encephalitis, endocarditis, hemolytic anemia, hepatosplenomegaly, glomerulonephritis, pneumonia, relapsing bacteremia, and osteomyelitis.
Psychological treatments could help patients come to terms with their emotions and treat mental illnesses they may develop, including depression, panic disorders, and anxiety disorders [ 9].
Additional potential mechanisms of acquired resistance to EGFR TKIs may develop, including altered EGFR trafficking, amplification or activation of downstream or overlapping pathways and expression of drug-efflux transporters.
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Newer issues that may develop include insurance concerns, worry about the health of children, and worry about the family's future in the event of recurrence [ 6, 11, 15].
On the negative side of identifying FMR1 premutation carriers at the time of birth is that the family is told of possible future problems related to the premutation that may or may not develop, including FXTAS, and this may cause excessive worries for the family, especially since the certainty of problems will be unknown.
Recruitment requires skills which GPs may lack opportunity to develop, including confident explanation of study requirements and accepting patient choice to not participate [ 14].
Building on Oliver Williamson's analysis of markets and hierarchies [ 11, 12], much recent scholarship has examined the intermediate governance forms that may have developed, including the mix of centralised and decentralised instruments used to control public-sector quasi-markets [ 14].
Systems of more formallly considering the value and worth of global health interventions from a 'foreign policy' perspective may be developed, including such considerations as community acceptance and involvement, so that such they can be monitored and evaluated on this basis [ 23].
However, visual threatening complications may develop, rarely including rhegmatogenous/tractional retinal detachment (R/T RD) and proliferative vitreoretinopathy.
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