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Background: Hypertension may develop early, before the age of 40 years, in both genders, so-called young-onset hypertension.
Although multiple basal cell carcinomas may develop early in life as an inherited trait (nevoid basal cell carcinoma syndrome, or as a complication of xeroderma pigmentosum), most arise in middle age and later.
The reduction of PDH expression, and the concurrent increase in pyruvate carboxylase gene expression, was discussed by Landfield et al. [38], who argue that: "These changes suggest that reduced pyruvate flux through PDH and decreased oxidative metabolism of glucose may develop early in AD.
Vasoconstriction in preeclampsia may develop early in pregnancy.
Patients with monogenic obesity may develop early onset of obesity and severe metabolic abnormalities.
Joint contractures may develop early, and affected children fail to thrive.
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The disease may develop earlier in life in each successive generation.
The induction and detection of TGF-β positive CD8+ T cells in the course of HIV disease is still unknown but may develop earlier in HIV disease [44].
Some authors have theorized that a similar process contributes to the development of FPHL, a concept supported by the observation that women with hyperandrogenism may develop early-onset FPHL [ 2].
Symptoms may develop earlier in cystic duct adenocarcinoma than in GB cancer.
However, a cartilaginous pre-form of the osteophytes may develop earlier, but is not detectable on the micro-CT images.
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