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Immunocompromised persons may develop chronic hepatitis E, but the relevance of endemic HEV for immunocompetent persons remains largely unknown.
Children unable to lose weight as they grow older may develop chronic and life-threatening diseases such as Type 2 diabetes and heart disease.
However, more than half of these patients, particularly those who receive either delayed or inadequate treatment, may develop chronic disease with consequent poor visual prognosis due to cataract, glaucoma, subretinal fibrosis, choroidal neovascularization, or choroidal atrophy [2].
Patients suffering from endometriosis may develop chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility [ 1].
The authors suggest that women may develop chronic musculoskeletal disorders at an earlier age than men.
In Siberian Russia and China, growing children with selenium deficiency may develop chronic osteoarthropathy (Kashin-Beck disease) [ 7].
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However, 80% of acutely infected people are not effectively cleared of HCV infection, and these patients may further develop chronic infection, suggesting that HCV has developed strategies to escape or to counteract the host immune response, leading to the emergence of resistance to IFN therapy.
Unfortunately, approximately 10 20% of patients may develop the chronic form of CH, without any remission period of more than a month (chronic CH).
Although the lungs of people with the ailment appear normal at birth, patients may develop pneumonias, chronic lung disease and other lung complications in their early years.
Without treatment, episodes of acute gout may develop into chronic gout with destruction of joint surfaces, joint deformity, and painless tophi.
Most patients with schizophrenia may develop a chronic course and are required for long-term maintenance treatment [7].
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