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What it means, the study said, is that more women may develop breast cancer that is not found until it is harder to treat.
Regardless of the level of risk, most women believed that they may develop breast cancer in their lifetime.
Although accurately recalling risk level does not necessarily accord with women's perception of their vulnerability (Hopwood et al, 2003), in this study the high-risk women were more likely to believe that they may develop breast cancer in their lifetime.
36– 38 Interestingly, at the time ospemifene was approved, the FDA required that its labeling include a boxed warning similar to estrogen-based products, a warning considered unwarranted by some, 48 as well as a warning against its use in women who have or may develop breast cancer.
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Moreover, studies have pointed out that chronic pain syndromes may develop after breast surgery that could be, at least partly, related to the intensity of acute postoperative pain and axillary nodes dissection [ 4].
About 800 of these women may go on to develop breast cancer – the UK's commonest form of cancer, claiming 12,000 lives a year.
Among women with BRCA1/2 mutations, nearly 50% may be expected to develop breast cancer by age 50 years [ 13].
Along these lines, our results suggest that our measures could be used to determine which women may be more likely to develop breast cancer after RRSO and could potentially benefit from alternative risk reduction interventions such as prophylactic mastectomy.
This suggests that women with a young AFP who develop breast cancer may be more likely to have ER-negative, high-grade tumors, which could explain the association between early first pregnancy and poor prognosis reported in some studies.
Women who develop breast cancer may have a higher bone density than those who do not, presumably secondary to effects of lifetime exposure to circulating estrogen which has been linked to increased risk of breast cancer (Nguyen et al., 2000; Heshmati et al., 2002).
Although pregnancy, pregnancy hormonal environment, and soy exposures during pregnancy in affecting mother's risk are not discussed in this review, the mechanisms by which pregnancy alters susceptibility to develop breast cancer may be relevant in explaining the protective effects of prepubertal genistein and oestrogen exposures.
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