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Although atherosclerosis occurs to a certain degree in all people, people with FH may develop accelerated atherosclerosis due to the excess level of LDL.
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However, APP/CCR2−/− mice develop accelerated amyloid angiopathy and shortened lifespans.
Sirt3− / − mice developed accelerated obesity, insulin resistance, and hyperlipidemia.
These results suggest that accelerated aging symptoms may develop in most of the mosaicked transgenic fish whose cells carry a functional zprogerin or zprelamin A transgene that is sporadically expressed.
Individuals exposed to lifestyle-associated vascular risk, such as cigarette smoking, hypertension, and hypercholesterolemia, may develop subclinical macrovascular disease, evident in lower ABI, and also may experience accelerated late-life cognitive decline.
Given the importance of mutant SOD1 protein dose in accelerating the ALS-like phenotype (16), it is possible heterozygotes may develop UMN loss later in life.
As suggested by Konopka et al. the mutations in PTEN gene region encoding C2 domain may develop in the initial stages of neoplastic process but participation of other genes is indispensable to accelerate its progression [ 22].
"Alternate identities may develop instead".
With time, though, differences may develop.
One day a planned interdependence may develop.
Hemorrhoids may develop.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com