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Moreover, we summarize the recent progress on the proteolytic activation of PEDV S proteins, and discuss factors that may determine tissue tropism of PEDV in vivo.
However, these adhesins may also bind to other receptors which may determine tissue tropism.
The decreased gut perfusion may determine tissue necrosis with subsequent translocation of bacteria that promotes the development of sepsis in the postresuscitation phase [ 34].
This variability of the ligands may determine the binding preference for distinct members of the CEA family which represents one mechanism that may determine tissue tropism (Virji et al., 1999; Bos et al., 2002; Gray-Owen, 2003; Hauck and Meyer, 2003; de Jonge et al., 2003).
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High genomic similarity of isolates from same tissues was found earlier [ 12, 19] and points to specific genotypes that may determine Cpn tissue tropism.
The physico-chemical properties of collagenous matrices may determine the tissue response after insertion into full-thickness articular cartilage defects.
The cellular source and type of Wnt proteins expressed in response to injury and their target cells may determine whether tissue regeneration or fibrosis occurs.
It is unlikely that these differences in relative selectivity are due to differences in such photophysical parameters as optimum activating wavelength (which would affect tissue penetration by light), or light absorption, and physicochemical factors that determine tissue localisation may be involved.
The selection of appropriate scaffold architecture with suitable pore mesh has long been recognized as the key factor that may influence the mechanical strength and determine tissue remodelling [ 18].
Critical host factors that protect the RPE from oxidative injury may determine its susceptibility to tissue destruction or modify the intensity of inflammatory reaction associated with AMD.
A further study in patients with de novo early stage disease, using paired serial imaging and tissue sampling to investigate early response to preoperative run-in targeted therapy, may determine whether imaging can replace tissue biomarkers.
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