In addition, in the past years muscle magnetic resonance imaging (MRI) has been applied increasingly to determine distinct patterns of muscle involvement, which may point to a specific genetic subtype [3,11].
Several TR-regulated genes determine distinct aspects of muscle biology.
The relative abundance, binding affinity and mode of interaction of the B56 isoforms to BubR1 and Sgo1 in a given cell type may determine the preferential localization of distinct PP2A B56 holoenzyme to either centromere or kinetochore.
Our findings show that although common general mechanisms may be utilized for positive and negative regulation, in a given target gene such as TSHα, different co-factors as well as histone modifications at distinct sites, may determine positive versus negative regulation of transcription.
This variability of the ligands may determine the binding preference for distinct members of the CEA family which represents one mechanism that may determine tissue tropism (Virji et al., 1999; Bos et al., 2002; Gray-Owen, 2003; Hauck and Meyer, 2003; de Jonge et al., 2003).
We have shown that these subtypes have distinct biological characteristics that may determine their clinical impact.
These data indicated that distinct DNA methylation profiles, which may determine tumor aggressiveness and patient outcome, have already become established at the precancerous stage.
Taken together previous reports of KS expression and functional recovery after neuronal injuries, our present study suggest that distinct inflammatory milieu in the CNS may determine expression profiles and biological roles of KS.
These results suggest that DNA repair pathways other than HR may determine sensitivity to PARP inhibitors and highlight the likelihood that ostensibly distinct DNA repair pathways cooperate to maintain genomic stability and cellular viability.
The difference in the CAIX plasma level may reflect distinct molecular pathways and genetic alterations that impact small-sized tumours, which may determine the subsequent development and risk of progression, as already suggested for bladder cancers (Turner et al, 2002).
