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Specific chromatin marks or other transcription factors yet to be identified may determine cell context dependency for differential NotchIC binding.
By silencing genes that are consistently repressed following drug exposure, we can mimic drug response and identify 'cytotoxic' genes within expression array datasets that may determine cell fate.
Culture medium in in vitro culture represents microenvironment in in vivo condition and may determine cell fate and thus cell secretion [ 37].
The difference in co-localization patterns between GM12878 and K562 cells explains the differential expression in genes that may determine cell states.
These intracellular signalling pathways may determine cell fate, for example, death, survival, proliferation, and release of hormones, and may be triggered by mechanical, chemical, light, and thermal stimuli.
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Therefore, not only PHB proteins levels but also its activity may ultimately determine cell fate.
Moreover, although root epidermal patterning in the EGL3 T399A -GFP transgenic plants was normal, the number of root hairs in EGL3 T209A/T213A -GFP plants was significantly reduced, likely due to a misspecification of non-hair cells in the H position, suggesting that the nucleus-localized EGL3 in H cells may determine N cell fate specification.
Our findings support that chronic exposure to low air pollution levels may determine early cell damage.
Inbred and recombinant inbred strain variations in adenoma growth patterns indicate that another set of genes, which we have designated pah for pulmonary adenoma histogenesis, may determine which cell type becomes neoplastic and whether adenomas will undergo malignant conversion.
In addition, SNPs in genes that control cell cycling and checkpoints may determine whether cells with substantial DNA damage and instability progress to replication or undergo apoptosis [ 5, 14].
It has been demonstrated that the regulated expression of glycosyltransferases during development and activation, creating N-acetyllactosamine ligands, may determine T-cell susceptibility to galectin-1-induced cell death (Galvan et al, 2000; Amano et al, 2003).
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