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This result suggests that differences in intracellular context or protein-protein interactions may determine activity of SIRT6 with respect to the regulation of apoptosis.
The cognitive state may determine the weight of either connection or else it may determine activity levels in the inhibitory neurons via connections from areas other than premotor cortex.
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Presumably, BSP expressed by diverse cells types is modified differently, and variations in post-translational modifications may determine the activity of these proteins and the binding and activation of proMMP-2.
Because the spatial and temporal dynamics of cold receptor cell-surface residence may determine neuronal activity, we hypothesized that the movement of TRPM8 to and from the PM might be a regulated process.
In light of our findings, we speculate that NMN concentration may determine this activity.
This has spawned the concept that variations in co-substrate levels may determine enzyme activity and direction in the brain in vivo [139,179,181].
The underlying reason for this was the fact that many TFs are post-transcriptionally regulated and relying on their expression to determine activity may lead to missing important TFs.
Controlling mitochondrial remodeling process is not only important for maintaining mitochondrial morphology but also for mitochondrial functions, which may determine the cellular activity and survival [17].
Oxygen supply, hence, may determine hepatic metabolic activity and compartmentation in septic shock.
Accordingly, the relative proportion of cells in each state may determine the overall activity of the PT, and hence the phase of the circannual cycle, as the PT reverts to a winter-like state after prolonged LP exposure, the proportion of CHGA+ cells increases as EYA3 and TSHβ decline.
Since different cell types may have different levels of protein expression for each co-regulator, the overall balance of co-regulatory proteins with activating and repressing activity may determine whether tamoxifen has an estrogenic or anti-estrogenic effect.
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