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Although serum CEA may detect recurrence, it does not identify the site of recurrence.
After local ablative therapy, PET may detect recurrence of liver metastasis earlier than CT [ 3, 21], but correlation with CT is needed for more exact localization [ 8].
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1 The aims may be to detect recurrence of tumour, to monitor late effects of treatment, to collect data and to offer patients an opportunity to raise concerns or anxieties arising from their cancer.
While diagnostic imaging may be relied upon to detect recurrence after 5 years of recurrence-free survival, studies in both pediatric and adult patients with HL have suggested that relapses are symptomatic and that routine CT, in addition to being expensive, has poor specificity and provides minimal overall survival benefit [ 47, 48].
Studies have reported that PET imaging may be of help in patients to detect recurrence due to the high tumor to background FDG uptake.
Recurrence rates and detection: use of PSA according to protocol 49 and time to detect recurrence.
However, longer follow up may be needed to detect recurrences.
This may have been useful to detect recurrences that occur <10 years post resection with 80%% of recurrence detected on follow-up.
There are several possibilities that can be considered when evaluating the possibility of surgical reconstruction after the first cancer resection, such as microvascular free flaps or rotation flaps, but it is sometimes necessary to monitor the healing process and the defect site in order to readily detect recurrences that may occur in high-risk patients [4, 5].
Early dynamic contrast-enhanced images and apparent diffusion coefficient mapping may be useful for detecting recurrence (Fig. 28) but they lack reliability.
This surrogate assay may be most effective for detecting recurrence of a typical FIP1L1 PDGFRA, but would not have resolved an interchromosomal event such as this one.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com