Under the compensatory model, substitutions that may destabilize protein structures or inhibit function could be compensated by a subsequent (or simultaneous) substitution at an adjacent site (Pollock et al. 1999).
However, accumulating recent evidence has demonstrated that silent mutations may destabilize RNA structures or disrupt cis regulatory motifs superimposed on coding sequences.
That is, each unstable end and mismatched base pair may destabilize hybridization of three or four neighboring base pairs, preventing hybridization of whole base pairs between the end and mismatched position.
These indel mutations may destabilize an essential regulatory structure or hamper gene function or, if located within coding regions of the gene, may cause frameshifts in the coding reading frame or otherwise alter the amino acid sequence of the protein product of the gene.
Expanding upon previous mechanistic models, it can be hypothesized that some mutations, particularly those with extensive deletions or insertions, may destabilize the DNA structure in ways that directly promote CN-LO Hduring mitotic recombination or during failed attempts to correct the mutant allele.
The closure of a bus route, the loss of a job or car, or the relocation of a clinical facility to another suburb or city, may destabilize a relational network and undermine its structural resilience.
Prp43 may destabilize base-pairings of U6/5′ splice site or U2/U6 by unwinding RNA duplex or by displacing proteins binding to specific RNA structures, which then triggers disruption of other RNA duplexes.
These results suggest that incubation at 70°C may affect regions of the D17N and E237Q mutants that are not rich in secondary structures, including loop regions, but that the structural perturbation due to the D17N or E237Q mutation may destabilize the active site conformation during a prolonged incubation at 70°C and above.
We have a crane here that can pick that up, but we just want to make sure there's nobody else alive that we can detect with the dogs or devices, because in doing that you may destabilize the pile of rubble and fall further onto somebody.
Neglecting the effective integration of Saudi youth in the public sector and more importantly private sector may further radicalize the disenfranchised youth which will ultimately threaten national security or encouraging them to join radical groups which may destabilize the region further.
