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With the new strategy, the drug associates tightly to the carrier and releases slowly, which may decrease toxicity and promote tumor accumulation via the enhanced permeability and retention effect.
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For example, a transformation may systematically decrease toxicity or increase lipophilicity of chemical compounds.
This aging step may increase or decrease toxicity.
Application of S fertilizer may decrease Cd toxicity by insoluble CdS formation (Table 3), by which reduces mobility of Cd in soil (Hassan et al. 2005).
Indeed, numerous tests on cancer cell survival and proliferation revealed strong additive or synergistic effects of combinations anti-cancer drug/extracts from a plant that may decrease unspecific toxicity of anticancer drugs.
There is no evidence for a specific immunosuppressive therapy to be superior in graft oxalosis; however, replacement of mycophenolate mofetil by, e.g. azathioprine may decrease gastrointestinal toxicity.
Treatment with two different inhibitors with independent signalling pathways may decrease the toxicity of drugs by reducing the dose necessary to achieve the same effect.
It is worthy to note that longer domains (18 20 bp) may decrease cell toxicity by reducing the risk of off-target effects [ 19].
Overall, these data suggest that highly selective small molecule inhibitors of specific Cdks may be preferable in order to decrease toxicity.
Also, in view of the recognized lack of IFN-α dose-response in RCC, it may be that lower doses can decrease toxicity while preserving efficacy.
The reason why CCT resulted in no significant increase in toxicities may be increased use of IMRT (85.8 % vs. 71.1 %; p = 0.010) and timely management of toxicity, as IMRT may decrease esophageal and pulmonary toxicity compared with 3D-CRT by increasing target conformity [ 12, 13].
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