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On the other hand, they may decrease substrate suitability by competing for space (Zotz and Andrade 2002) or via allelopathic effects (Callaway et al. 2001).
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Statins are safe and inexpensive, and may synergize with novel antiandrogen agents abiraterone via pharmacokinetic interactions and decrease substrate availability for de novo androgen biosynthesis.
Although the liquefaction and solubilization of the substrate may decrease the probability of the enzyme to bind with the substrate, a surprisingly high yield, above 60% glucose of total, could be obtained even with the mixture of enzymes lacking the CBM after 120 hours.
In Figure 2A, most QDs were well dispersed on the smooth Ag substrate, which may decrease the quenching of PL by aggregation.
In addition, high concentration of substrates and products may decrease enzyme activity.
If cocaine induces CYP3A4 in humans as well, it may decrease levels and effectiveness of the many ARVs that are CYP3A4 substrates, including most NNRTIs and PIs.
The increasing demand for biofuel may decrease the dead wood supply in managed forests, and hence the amount of substrate available for dead wood dependent species.
These reports suggested that gefitinib may decrease the clearance of these drugs and it may be due to CYP3A4/5 substrate competition.
Thus, there may be a tradeoff between decreased substrate specificity and substrate inhibition, and decreased inhibitor inhibition with the maximization of all three impossible.
Since the maytansinoids are substrates for the MDR1 transporters [ 53], drug efflux by MDR1 may decrease the intracellular DM1 concentration, resulting in a decline in efficacy.
For some workers, hours may decrease.
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