This may decrease the specificity of individual clinical biomarkers in prodromal DLB, which may best be described by a pattern of symptoms accumulating over time.
On the other hand, it should be noted that the possibility of occasional tumour marker gene expression in non-malignant cells of breast cancer patients cannot entirely be excluded, which may decrease true specificity in a clinical setting.
Cross-reactivity of HC2 high-risk probe to HPV types that have a signifcant risk for cervical cancer may be considered as beneficial, but cross-reaction with low-risk types causing false-positive results may decrease the specificity and positive predictive value 141.
In future studies with CCC v2, however, investigators should keep in mind that the increased sensitivity in identifying children with complex chronic conditions may have decreased specificity.
Adding MUAC just seemed to decrease specificity.
Their inclusion as classification criteria for definite APS, however, may decrease the diagnostic specificity [ 1].
Failure to include timing of pesticide application when studying congenital malformations may lead to decreased specificity for exposure and biased effect estimates (Savitz et al. 2002a).
In fact, there is a balance in choosing the number of PCR cycles: too few may result in decreased specificity and insufficient amount of amplicons, while too many will distort the initial distribution of nucleic acid targets; so, the number of cycles should be optimized for each assay.
Specificity may decrease pollen loss, a factor that is likely important in orchids, given their highly efficient pollination via pollinia.
Although, specificity may decrease due to false positive cases, as some AKI cases had a similar prognosis as non-AKI cases.
