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One of these key loci is MLH1 where DNA methylation and resulting loss of expression of this DNA mismatch repair gene may decrease response to chemotherapy (Brown et al, 1997).
While in this study in a small subset of subjects we did not find that sedation affected functional activity; there is a need for a larger and systematic study of the specific effects of sedation on BOLD responses in infants as there is also recent work suggesting that it may decrease response amplitude (Williams et al. 2015).
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Two RCTs have found that use of d-cycloserine did not enhance the overall treatment effects of exposure therapy [ 953, 954], and may in fact decrease response to psychotherapy [ 954].
Many studies have shown that the reproductive success of individual plants may decrease in response to increasing NND or decreasing LNS due to pollen limitation (Allison, [1990]; Roll et al. [1997]; Jakobsson et al., [2009]; Caraballo-Ortiz et al., [2011]).
Use of analgesics may decrease stress response in critically ill patients [ 46, 47].
Although peripheral tryptophan may decrease in response to LPS, the availability of tryptophan to the brain remains unchanged and brain tryptophan may even increase (O'connor et al., 2009).
Thus, miR-150-5p up-regulation may decrease immune response to PAH exposure and make individuals more vulnerable to the deleterious effects of PAHs.
OIC encompasses both peripheral and central elements; peripherally, the opioid receptor activation delays gastric transit, reduces secretions, and promotes the reuptake of water and electrolytes, whereas centrally the opioids may decrease autonomic response in the gut (6).
Participant fatigue or irritation may decrease accuracy of responses, introduce non-response or even cause the interview to be terminated.
One of the more exciting findings is that NMBAs may decrease the inflammatory response associated with ARDS.
Note that some factors may increase the likelihood of a response (i.e., decrease the minimum dose required for a response), while others may decrease the likelihood of response (i.e., increase the threshold dose).
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