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They must be assessed by a panel who may decide patients are not suitable if there is unlikely to be a clinical benefit from the treatment.
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As healthcare workers may decide to punish patients who do not live up the 'good patient persona', many patients seek to perform within the confines of the 'good patient persona' to access good care and ensure continued access to ART.
Doctors may decide to screen patients for various genetic disorders, like Tay-Sachs disease, based on a family's medical history.
A physician, for example, may decide that a patient needs an organ transplant.
If the gaps in knowledge are not filled with informative rigorous data, future regulators and payers may decide how a patient will be treated.
The program thus emulates history-taking by a physician, who may decide as the patient's story develops to switch a line of inquiry to pursue alternate pathophysiologies.
A clinician may decide that a patient is responding poorly to their allocated treatment and it is therefore unethical to let them continue on this regime.
If patients are identified as being in the terminal phase (last 48 hours of life), this will be discussed urgently with the clinical team who may decide that the patient should be transferred to Liverpool Care Pathway [ 12].
Non-liver specialists may decide that the patient is ineligible for treatment based on a list of contraindications, whereas liver specialists may otherwise safely treat the patient with relative contraindications (i.e. patients with cirrhosis and moderate thrombocytopenia) since most treatment regimens are individualized to achieve maximal sustained virological response.
Whereas current Dutch guidelines for general practitioners advise a wait-and-see policy for all patients with shoulder pain at first, they may decide to monitor those patients with a worse prognosis more frequently and alter the treatment plan timely if complaints persist.
Reasons to terminate a patient's participation include: The patient withdraws her/his consent Intolerance to the study drug: if a patient experiences unacceptable side effects, the patient may decide, or make a joint decision with the treating physician, to terminate study participation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com