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At low doses, certain agents may decelerate aging and age-related diseases.
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Calorie restriction [ 129- 137] and rapamycin [ 138- 141], which decelerate aging, also postpone cancer.
What if this gerogenic force could be diminished to decelerate aging after the completion of development.
Thus, inhibition of the mTOR pathway is a strategy to decelerate aging in progerias [ 40].
Data showing that a drug can increase lifespan are the first step in developing the case that the drug can delay or decelerate aging.
Results from genetic studies recently indicated that manipulation of genes restrictedly in specific hypothalamic nuclei could accelerate or decelerate aging process in mice [ 18- 21].
Thus individuals with naturally decelerated aging rates may be less susceptible to exogenous toxins such as cigarette exposure.
While decelerating aging, inhibition of mTOR may decrease robustness, tolerance to infections, cold temperatures and famine.
Calorie restriction (CR) decelerates aging.
In fact, calorie restriction, which deactivates mTOR and decelerates aging, partially substitutes for the loss of p53 in mice.
Metformin disrupts the bacterial folate cycle, leading to reduced levels of SAMe and decelerated aging in the worm.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com