Sentence examples for may critically regulate from inspiring English sources
Interactions with these residues may critically regulate TPH function and thus serotonin synthesis.
Further complicating the studies of prognostic significance is the finding that subcellular localization of PTK6 protein may critically regulate oncogenic activity; in studies of prostate tumor cells, cytoplasmic localization of PTK6, in contrast to nuclear expression, was associated with poor differentiation and androgen independence, which are adverse prognostic factors [46].
Among these residues, tyrosine sulfate residues may critically regulate PSGL-1 interactions with L- or P-selectin, like in human PSGL-1 [ 16, 18, 22, 45].
Some lncRNAs physically associate with neural TFs such as REST or epigenetic modulators PRC2, implying that lncRNAs may critically regulate neural trans-differentiation.
Moreover, the findings suggest that nicotine may critically regulate brain areas that are involved in the inhibition of negative emotions such as anger [ 43].
Thus Ca2+ release via TPC2 may critically regulate the intraluminal pH of lysosomes and thereby modulate the activity of pH-sensitive hydrolytic lysosomal enzymes, such as glucocerebrosidase, which exhibits a marked loss of function at pH > 5 (76, 100) and may lead thereby to consequent accumulation of macromolecules, such as glucocerebroside.
NO bioavailability may be critically regulated by arginase by competing with NOS for their extensive substrate L-arginine [ 37].
An emerging body of evidence, however, supports the concept that tumors may also be dependent on the same lineage-specific transcription factors which critically regulate the normal tissue restricted developmental progenitor cells[50], [51], [67].
We aimed to identify molecules that critically regulate IGF-1-induced anchorage-independent survival.
STAT6-dependent pathways critically regulate eosinophil migration into the lung, that involves the induction of eotaxin-1 and -2 expression.
Thus, FXR is known to critically regulate nascent bile formation and bile acid (BA) enterohepatic circulation.
