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It can be therefore suggested that although SWS supports the reorganization of implicit task representations (present results) and their transformation to explicit memories [26], there are additional factors that may critically modulate the probability for subsequent post-sleep insight solutions.
Our data combined with previous studies suggest that TGFβ is not only a central mediator involved in the inflammatory and fibrotic phase of healing and may critically modulate many cellular steps in post-infarction cardiac repair [ 11, 17, 42], but can also induce EMT of epicardial cells.
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Thus Ca2+ release via TPC2 may critically regulate the intraluminal pH of lysosomes and thereby modulate the activity of pH-sensitive hydrolytic lysosomal enzymes, such as glucocerebrosidase, which exhibits a marked loss of function at pH > 5 (76, 100) and may lead thereby to consequent accumulation of macromolecules, such as glucocerebroside.
In these experiments we identified three variables that critically modulate the effect of the repeated ethanol exposure: sex, context and age.
Alcohol has been shown to critically modulate cyclic adenosine-3′,5′ monophosphate (cAMP) signaling.
MiRNAs critically modulate many cellular events, including the balance between proliferation and differentiation during organ development [ 1].
A reciprocal gradient of Draxin might shape or sharpen the active Netrin gradient, thereby critically modulating its effect.
Cytokine secretion is critically modulated by JAK/STAT activity [ 104].
However, this relationship was critically modulated by systemic inflammation.
These functional effects of the dimorphism were critically modulated by the MICA expression intensity.
Thus, the selenite-regulated PTEN/AKT/FoxO3a/Bim signaling hub and apoptosis are critically modulated by ROS in HCT116 and SW480 cells.
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