Sentence examples for may critically alter from inspiring English sources

In addition, in silico analysis of 3D structures can facilitate variant prioritization because it provides systematic screening of nsSNP effects in the context of the protein structure and suggests which mutations may critically alter the function of the protein.

More recently, fascinating insights from X-ray crystallographic studies have indicated that there may be rare (hidden) conformations and sub-states that critically alter the active site environment for catalysis [20].

If, for example, a fragment of protein is made, this would critically alter the interpretation.

We therefore hypothesized that stromal influence on epithelial cells could critically alter the migration pattern of tumor epithelial cells.

We thus conclude that LXs may regulate Abcb11 with higher specificity than LTs and speculate that exogenously administered LXs could have critically altered lipid mediator homeostasis in the liver, thereby decreasing Abcb11 expression.

The loss of his daughter critically altered his once-tentative grasp on his own accountability.

Said waste has critically altered the local ecosystem.

However, the occurrence of severe pathophysiological changes, namely the fluid shift phenomenon [5] and augmented renal clearance [6], in critically ill patients may alter the pharmacokinetics (PK) of the antibiotics.

Pharmacological agents used to treat critically ill patients may alter mitochondrial function.

However, the occurrence of severe pathophysiological changes, namely the fluid shift phenomenon [ 5] and augmented renal clearance [ 6], in critically ill patients may alter the pharmacokinetics (PK) of the antibiotics.

If these alterations reflect preconditioning, our results suggest that this phenomenon may be altered in critically ill patients.