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CTCF may control epigenetic modifications by binding to the chromatin remodeling factor CHD8 [ 11].
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The emerging evidence indicates that these RNAs may control the epigenetic states of cells by targeting chromatin modification complexes and that their expression is deregulated in cancer and other complex diseases [ 38].
A recent example showed that a locus-specific epigenetic remodeling may control cocaine addiction- and depression-related behaviors [ 125].
Several of the corresponding genes have subsequently been shown to encode members of chromatin-modifying complexes, such as NuRD acting during vulva formation [ 2] and Polycomb affecting germline survival [ 3], thus providing molecular insight as to how epigenetic changes may control development.
Another unexplored mechanism could be related to epigenetic factors that may control CP gene expression at the chromatin level.
Therefore, it may be postulated that phenotypic variation in the response to LPS between individuals may be partially controlled by epigenetic modification.
Since DHCR24 activity is a major determinant of relative pathway utilization, cell-type specific control of pathway utilization may involve epigenetic control of DHCR24 expression.
This important concept suggests that transcription of the E-cadherin gene, or post-translational modification, may be partly controlled by epigenetic mechanisms.
It will be important now to expand studies of IS in T cell subpopulations isolated from patients on long-term therapy to determine how viral expression may be controlled by particular epigenetic markers and gene-specific control mechanisms in the specific subpopulations that contribute most to the size of the latent reservoir.
A simple preventive strategy as periconceptional folic acid use may affect epigenetic control and as such may link the prevention of intrauterine development, i.e., birth defects such as neural tube defects, and growth due to a loss of imprinting with the risk of chronic diseases in these children throughout life.
The underlying regulatory mechanism may involve epigenetic mechanisms controlling mammary gland development that remain preserved during malignant transformation (Stingl and Caldas, 2007; Rijnkels et al, 2010).
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